Polygenic indexes

Our Aim

We aim to generate and make polygenic indexes (PGI) available for all CLS cohorts using a standardised pipeline which is transparent, efficient, and updatable. Our approach to sharing these data seeks to balance the need to make data available to enable research with the ethical need to avoid potential risks.

PGI will be derived for multiple health and social traits (below), and made available on the UKDS via special license agreement.

We are aiming for a full release of the PGI in 2025, though this is dependent on internal capacity. We will email genetics data applicants when the data are available. For further updates please email clsdata@ucl.ac.uk.

In the interim, we have a selection of PGI that can be obtained via application to the CLS DAC (see Introduction). These PGI are available for the NCDS, BCS, Next Steps, and MCS (parents and children).

Current PGI available via the DAC (last updated 31/03/2025)

Forthcoming additional PGI for full release

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